Endocrine Abstracts

Purpose: The present study aims to investigate the effects of hyperprolactinemia (HPRL) and its pharmacological control with Cabergoline (CAB) on the risk of fractures in male patients affected by prolactinoma.Methods: Observational single-center study was conducted on 39 male patients (median age 49±12,4 y) with prolactinoma, including 37 with macroprolactinoma and 2 with empty sellae. In patients PRL levels at diagnosis (PRL 0’), PRL at evalu...

Purpose: Dopaminergic system is implicated in the development of sleep disorders, and dopaminergic agents are used in clinical practice to treat daytime sleepiness and sleep disorders. The present study aimed at investigating the effects of hyperprolactinemia and its control with dopamine-agonists (DA) on sleep quality, excessive daytime sleepiness (ESS) and risk of obstructive sleep apnea syndrome (OSAS) in prolactinomas.Methods: A single-centre study w...

Rationale: Type 2 diabetes mellitus (DM) is common in patients with Cushing’s disease (CD) and Acromegaly (AC), and contributes to increased mortality. This study aimed at investigating the prevalence and characteristics of DM in CD and AC patients at diagnosis and after disease control (DC).Patients and Methods: 34 CD patients (8M,26F, 24 microadenomas(mA),6 macroadenomas (MMA) and 4 empty sella) and 35 AC patients (16M,19F, 7 mA,28 MMA) were inclu...

Context: Although diabetes mellitus is a major complication in patients with acromegaly, prevalence and determinants of microvascular and macrovascular complications of diabetes remains unexplored in this population.Aim: To investigate prevalence and determinants of microvascular and macrovascular complications in acromegaly patients with diabetes and to compare them with a group of diabetic patients without acromegaly.Methods: Pro...

Context: Prolactin (PRL) exerts a crucial role in the regulation of mammalian reproduction and in the promotion of lactation as response to the suckling reflex. Beyond this, it directly modulates gluco-insulinemic metabolism.ObjectiveTo dissect glucose metabolism during and after pregnancy in patients with chronic hyperprolactinemia (CTPE).MethodsThis longitudinal study included 52 reproductive aged women with CTPE due to pituitary adenomas (43 microadenomas, 9 macroadenomas),...

Purpose: The present study aimed at investigating the morphology and function of reproductive system in women with hyperprolactinemia (HPRL) receiving chronic treatment with cabergoline (CAB)Methods: Twenty-three women(aged 34.21±10.09 yrs) with HPRL, including 17 with microprolactinoma, 3 with macroprolactinoma and 3 with iatrogenic HPRL, entered the study. All patients were well-controlled with CAB treatment (medium dose 0.46±0.45 mg/week). In po...

Rationale: The gluco-metabolic changes during pregnancy significantly impact women’s sexual behavior. This study aimed to define the relationship between metabolic health and sexual function, along with human circadian rhythms and sleep quality during pregnancy.Methods: This study included 57 pregnant women (14 evaluated at first trimester, G1; 18 at second trimester, G2, and 25 at third trimester, G3). Among groups, no difference between age, gesta...